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 广州出生队列研究项目进展

  广州市妇女儿童医疗中心主持的广州出生队列研究拟对在广州市分娩的30000名孕妇及其所生儿童进行长期的随访,并建立中国最大的正常人群亲子生物样品库,运用流行病学研究方法,探讨影响广州地区儿童和妇女健康的主要因素,测量社会、经济、文化、生物、环境等因素在影响这一弱势群体中的作用及其作用机理,从而验证一系列不良妊娠结局和儿童期疾病的病因假设,为提出改善儿童和妇女健康状况的干预措施提供科学依据,同时为改善医疗卫生服务,制定相关的医疗服务指南及政策提供依据。

  项目从2010年开始着手筹建,于2012年2月正式启动生物样本库基础建设,项目严格按照预期推进。至2016年12月已招募23084名孕妇入组,并如期随访。现已分娩17714人,其中双胞胎393对,三胞胎1对。入库各类标本(外周血项目从2010年开始着手筹建,于2012年2月正式启动生物样本库基础建设,项目严格按照预期推进。至2017年09月已招募30,020名孕妇入组,并如期随访。现已分娩23,529人,其中双胞胎503对,三胞胎1对。入库各类标本(外周血、脐血、脐带、胎盘、干血片)152万余份。

  队列日常运营管理水平达到国际同类队列水平,入组率达70%,婴儿1岁时随访率超过85%;综合运用微博、博客、QQ群、短信平台管理人群,各期随访率逐步提高。队列生物样本库已完成基础建设,拥有26台超低温冰箱和16台大型液氮储存箱。信息系统实现实时诊疗信息推送,动态数据更新,生物样品实现可视化管理。

  出生队列平台支撑了25项国家、省市级重大科研项目。其中国家重点研发计划子课题2项,国自然项目6项,国家CDC项目1项,省自然项目3项,省科技项目5项,省卫生经济1项,广州市科信局对外合作项目2项,重大民生项目3项,市卫计委1项以及临床医学研究与转化中心1项; 累计获科研资助约3286万元。2013年1月至2017年9月,发表27篇SCI论文。约3221万元。

  出生队列已成为我院重要的对外学术交流合作平台,与多个世界一流的机构和大学建立战略合作伙伴关系,如比尔盖茨基金会和英国牛津大学等。每年组织学术交流30余次,与英国牛津大学、伯明翰大学、加拿大不列颠哥伦比亚大学和香港大学进行定期交流。我方出国学习、研讨交流多达20次,并与伯明翰大学共同培养1名博士研究生。

 

 Project Progress

The Born in Guangzhou Cohort study established in 2010. In February 2012 officially launched biobank infrastructure and the project strictly carries on accordance with the expected progress. To September 2017, it has recruited 30,020 pregnant women with schedule follow-up. There are 23,529 childbirth, including 503 pairs of twins, 1 pair triplets. Stored various specimens (peripheral blood, cord blood, umbilical cord, placenta, dried blood spots) were more than 1,520,000 servings.

Our daily operational management level already reached the international level of the cohort studies in the world, recruitment rate of 70%, follow-up rate of over 85% at 1 year old. We integrated use of weibo, QQ group, the SMS platform to manage participants in groups, each of follow-up rate gradually increase. The biobank infrastructure has been completed, with 26 sets of ultra-low temperature freezer and 16 large liquid nitrogen storage tanks. Information systems achieved for real-time medical information delivery, dynamic data update, as well as biological sample visualization management.

The platform of Born in Guangzhou Cohort Study (BIGCS) supports 25 research projects, including 9 national projects, 9 provincial projects and 7 municipal projects. The total funding reaches 32.86 million RMB. From January 2013 to September 2017, the team of BIGCS published 27 papers.

Born in Guangzhou Cohort Study has become an important platform for international academic exchange and cooperation in our medical center, to establish strategic partnerships with a number of world-class organizations and universities such as Bill & Melinda Gates Foundation, university of Oxford, etc. Each year we have organized in more than 30 times academic exchange with the University of Oxford, University of Birmingham, University of British Columbia and the University of Hong Kong conducted a regular academic exchange. We also send colleague to study abroad, have academic exchange and attend various international meeting over 20 times, and incubated for 1 doctoral students with University of Birmingham recently.