出生队列出生缺陷（BD）亚队列
出生缺陷（BD）亚队列基于广州宝贝计划建立，主要招募胎儿被确诊患有某种类型的结构缺陷，且打算继续妊娠并计划在我院分娩的孕妇，收集孕期-产期流行病学资料及临床信息；在其宝宝分娩后1月龄、6月龄、12月龄、3岁时进行追踪随访，为宝宝提供免费儿童保健及发育评估测试，纵向监测生长发育轨迹及神经发育情况，关注不同类型出生缺陷胎儿的出生结局及童年期健康相关问题，探索各种类型出生缺陷的发生机制，以及相关的遗传、环境因素。
孕期随访及优惠
●20-28周间入组，要求入组时完成Q1G问卷，在24-28周完成Q2问卷，并留取大便样本，35周后完成Q3问卷；29周以后入组，要求入组时完成Q1G问卷，在35周后完成Q3问卷
●可以预约孕妇俱乐部收费课程，预约地点：产科门诊宝贝计划处
●父亲入组可免费测血脂
儿童期随访及优惠
●可免费获得1月龄、6月龄、12月龄、3岁（免挂号）儿童保健
●可免费获得6月龄、12月龄、3岁免费发育评估
●可赠送免费抽血项目
●由专科医生随访术后（出院后）外科情况，包括伤口愈合情况等
孕妇
自2014年5月启动以来，截止目前出生缺陷亚队列已入组孕妇127例。我们希望能与孕妈妈一起用心守护宝宝，监测宝宝生长发育轨迹。
Sub-cohort of birth defect
The sub-cohort of birth defect is one of the most important sub-cohorts from Birth in Guangzhou Cohort Study(BIGCS), and recruited pregnant women who had been diagnosed as having a baby with some type of birth defect. We collected information of mothers during pregnancy and infants and children at 1 month, 6 month, 12 month and 3 years old. We are going to examine the short-term and long-term health problems of the offspring, and to explore the mechanisms and genetic or environmental factors related to different types of birth defect.
Follow-up during pregnancy
●questionnaire Q1G between 20th and 28th gestational weeks, questionnaire Q2 and stool samples between 24th~28th gestational weeks, and questionnaire Q3 after 35th gestational week before delivery
●pregnancy club course
●blood lipids test for spouse
Follow-up during infancy and childhood
●health care at 1 month, 6 month, 12 month and 3 years old
●development assessment at 6 month, 12 month and 3 years old
●blood test
●follow-up by a specialist (after discharge), including wound healing.
There have been 127 pregnant women in the sub-cohort since May 2014, and we welcome more pregnant women to join us.